Brown roast in skillet on all sides; remove to roasting pan, reserving pan drippings. Add water, Heinz 57 sauce, soy sauce, salt and pepper to reserved pan drippings; mix well. Pour over roast.
Roast at 375F for 1 hour; baste with pan drippings. Reduce oven temperature to 300F. Roast for 1 hour longer, basting occasionally with pan drippings.